Tag: cellular signaling pathways
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Gene Therapy for Hemoglobin-Related Diseases: Progress and Challenges
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Hemoglobin-related diseases, such as sickle cell anemia and beta-thalassemia, are common single-gene disorders that affect millions of people worldwide. The challenges faced by traditional treatments for these diseases, which often focus on symptom management and stem cell transplantation, drive researchers towards developing new and more effective solutions. In this article,…
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Detection of Chromosomal Instability as a Diagnostic Tool for Predicting Lymph Node Involvement in Breast Cancer Pre-Surgery
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Breast cancer is one of the most common cancers among women worldwide, and its incidence rates have significantly increased in recent years. This type of cancer is characterized by a number of clinical challenges, particularly in assessing tumor spread and managing treatment stages. In this article, we highlight a new…
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Nanoparticle-Based Drug Delivery Systems for Ovarian Cancer Treatment: Mechanisms, Challenges, and Future Perspectives
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**Introduction** Ovarian cancer is one of the most dangerous types of cancer facing women, representing a major cause of cancer-related deaths worldwide. The diagnosis and treatment of this disease is a significant challenge due to the unclear symptoms in the early stages and the difficulty in managing its multiple developments.…
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Genetic Mutations in Multiple Endocrine Neoplasia Syndromes: Challenges and Strategies in Genetic Screening
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Multiple endocrine neoplasia (MEN) is a group of rare genetic disorders characterized by the development of multiple tumors in the endocrine system of the same patient. Since the introduction of the first type of MEN, MEN1, followed by MEN2A and MEN2B, the genes responsible for these syndromes have been identified,…
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Mechanism of Salmonella Strains Effect on Inducing Programmed Cell Death (Pyroptosis) and Its Implications for Animal and Human Health
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In the world of veterinary medicine and animal health, Salmonella is one of the most well-known pathogens associated with foodborne diseases, which often leads to severe infections in both humans and animals. Through this article, we will review the evolution of our understanding of the relationship between Salmonella and the…
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Benzastilbene and its Derivatives from Marine Fungi: Structural Diversity and New Biological Activities in Drug Development
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Marine fungi are considered one of the most prominent natural sources of bioactive secondary metabolites, providing a vast treasure of active compounds. In the context of this research, benzopyran compounds emerge as an important class of these natural products due to their remarkable structural diversity and notable biological activity. This…
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Genetic Modification in Relation to Neurological Diseases
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Inherited modifications (epigenetics) are considered sensitive and complex biological processes that play a pivotal role in gene regulation and their effects on cell function. This article demonstrates the significance of epigenetic mechanisms in neurological disorders, highlighting how these modifications are essential in determining the functions of brain and nerve cells.…
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The role of STAT1 in enhancing autophagy during classic swine fever virus infection using the CRISPR/Cas9 system
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Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction comes to light. This study addresses the role of the STAT1 protein in the autophagy process during infection with the Classical Swine…
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The Role of STAT1 in Enhancing Autophagy During Classical Swine Fever Virus Infection Using the CRISPR/Cas9 System
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Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction becomes prominent. This study addresses the role of STAT1 protein in the process of autophagy during infection with the classical swine fever…
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The Effect of Tanshinone II A in the Treatment of Liver Cancer: Exploring Mechanisms and Predictive Models Applied to Traditional Chinese Medicine
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Hepatocellular carcinoma (HCC) is considered one of the most serious types of cancers that threaten public health, representing about 85-90% of all primary liver cancers. Although surgical resection is the most effective treatment, most patients are diagnosed at advanced stages, depriving them of surgical options. In this context, alternative therapies…