Tag: Akt
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The Effect of Nothogenesid R1 Extracted from Banks Nothogenes on Insulin Secretion and Glucose Levels in Diabetic Mouse Models
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**Introduction** Throughout a long history, medicinal plants have been used to treat diabetes, a disease affecting hundreds of millions worldwide. The compound Notoginsenosides R1 (NGR1) extracted from the Panax notoginseng plant is one of the promising substances that has shown anti-diabetic effects in animal studies. However, the precise molecular mechanisms…
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Predicting Hepatocellular Carcinoma Outcomes Using a Novel Model Based on Anoxia Resistance and the Effect of the ERBB Pathway
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Hepatocellular carcinoma (HCC) is considered one of the most prevalent types of cancer, topping the list of diseases that pose a significant global health challenge due to its high mortality rate and low long-term survival rates. Despite remarkable advances in targeted therapy and immunotherapy, there remains an urgent need to…
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The role of exosomes in the diagnosis and treatment of liver cancer.
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In recent years, human health has faced increasing challenges due to the spread of malignant diseases, particularly liver cancer, which stands out as one of the most dangerous types. Liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, is one of the leading causes of cancer-related deaths worldwide. In this context,…
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The Role of Protein SUB1154 in the Immune Response of Dairy Cows Against Streptococcus uberis Infection.
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“Streptococcus uberis” is one of the pathogenic members of the pyogenic bacteria group and is considered a major cause of intramammary infections and mastitis in dairy cows. Despite its widespread distribution as an endemic pathogen, there is significant difficulty in controlling it worldwide, making it a major contributor to multiple…
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Nanoparticle-Based Drug Delivery Systems for Ovarian Cancer Treatment: Mechanisms, Challenges, and Future Perspectives
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**Introduction** Ovarian cancer is one of the most dangerous types of cancer facing women, representing a major cause of cancer-related deaths worldwide. The diagnosis and treatment of this disease is a significant challenge due to the unclear symptoms in the early stages and the difficulty in managing its multiple developments.…
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The Complex Relationship Between Chondrocyte Autophagy and Osteoarthritis
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Osteoarthritis (OA) is considered one of the most common types of arthritis in the world, characterized by the gradual degeneration of cartilage, which is closely associated with the autophagic processes of chondrocytes. These cells, which are the only elements found in articular cartilage, play a vital role in maintaining cartilage…
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The Complex Relationship Between Autophagy of Chondrocytes and Osteoarthritis
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Osteoarthritis (OA) is considered one of the most common types of arthritis in the world, characterized by the gradual deterioration of cartilage, which is closely related to the autophagic processes of chondrocytes. These cells, which are the only elements in articular cartilage, play a vital role in maintaining cartilage balance.…
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Mechanism of Salmonella Strains Effect on Inducing Programmed Cell Death (Pyroptosis) and Its Implications for Animal and Human Health
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In the world of veterinary medicine and animal health, Salmonella is one of the most well-known pathogens associated with foodborne diseases, which often leads to severe infections in both humans and animals. Through this article, we will review the evolution of our understanding of the relationship between Salmonella and the…
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The Role of Potassium Channels in Heart Injury Due to Reperfusion After Acute Myocardial Infarction
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The injury to the heart muscle resulting from the restoration of blood flow after a heart attack is one of the significant health issues that require attention and study. This phenomenon is known as MIRI (Myocardial Ischemia-Reperfusion Injury), as restoring blood flow to cardiac tissues may lead to severe damage…
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The role of STAT1 in enhancing autophagy during classic swine fever virus infection using the CRISPR/Cas9 system
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Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction comes to light. This study addresses the role of the STAT1 protein in the autophagy process during infection with the Classical Swine…
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The Role of STAT1 in Enhancing Autophagy During Classical Swine Fever Virus Infection Using the CRISPR/Cas9 System
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Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction becomes prominent. This study addresses the role of STAT1 protein in the process of autophagy during infection with the classical swine fever…
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Defining the Role of Chromatin Regulators in Lung Adenocarcinoma and Their Impact on Survival Outcomes and Immune Response
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Introduction: Lung cancer is a major source of cancer-related deaths, with incidence rates continuing to rise worldwide. Chromatin remodeling, as a vital biological process in regulating gene expression, is a key factor in the development and progression of malignant tumors. However, the role of chromatin regulators in lung adenocarcinoma (LUAD)…
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Viral Therapy as a New Approach to Cancer Treatment: Focusing on Multiple Myeloma
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Viral therapies used in tumor treatment, known as oncolytic viral therapy, are among the modern therapeutic approaches that have garnered interest in the medical community for treating certain types of cancer, including multiple myeloma. This article addresses a comprehensive discussion of the mechanisms by which oncolytic viruses target cancer cells,…
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The Effect of Tanshinone II A in the Treatment of Liver Cancer: Exploring Mechanisms and Predictive Models Applied to Traditional Chinese Medicine
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Hepatocellular carcinoma (HCC) is considered one of the most serious types of cancers that threaten public health, representing about 85-90% of all primary liver cancers. Although surgical resection is the most effective treatment, most patients are diagnosed at advanced stages, depriving them of surgical options. In this context, alternative therapies…
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The Importance of the Deep Ocean in Understanding Climate Changes: Opportunities and Threats
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In light of the increasing environmental challenges and the impact of climate change, the deep ocean is one of the most mysterious parts of our ecosystem, despite its significant importance. This article examines the potential significant risks arising from the lack of knowledge related to the role of the deep…
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Social Impacts of Modern Technologies: New Challenges and Opportunities
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In our contemporary world, the intertwining of technology in the fabric of daily life is undeniable. Technological innovations, such as artificial intelligence, financial applications, and wearable technologies, have contributed to comprehensive changes across various levels of society. With the increasing reliance on these technologies, both positive and negative outcomes emerge…
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Hydrogen: The Cornerstone of Clean and Sustainable Energy in the Future
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### Introduction: The Importance of Hydrogen in the Future of Energy As environmental and economic challenges increase globally, hydrogen emerges as a promising solution for a clean and sustainable energy future. This chemical element, which represents one of the fundamental building blocks of the universe, is among the most important…