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The Diagnostic Value of Modified Prostate-Specific Antigen Density in Detecting Prostate Cancer

Prostate cancer is considered one of the most common types of cancer among men, ranking second globally in terms of incidence rate. The challenges arise in the accurate diagnosis of this disease, as many clinical methods rely on specific measurements of prostate-specific antigen (PSA) levels. However, using PSA as the sole indicator may lead to false results since elevated levels may be associated with non-cancerous conditions such as benign prostatic hyperplasia. In this context, the current research presents an innovative study aimed at evaluating the effectiveness of modified prostate-specific antigen density (PSADadj) as a diagnostic tool for prostate cancer. By analyzing data from 410 patients who underwent prostate biopsy, the researchers explore the potential benefits of this new indicator, contributing to improved diagnostic accuracy and assisting doctors in making better decisions regarding biopsy procedures. We will review the details of this important study and discuss the key findings and future applications of the PSADadj indicator in the diagnosis of prostate cancer.

Introduction to Prostate Cancer and PSA Usage

Prostate cancer is among the most common types of cancer in men, ranking second in prevalence and fifth as one of the leading causes of cancer deaths worldwide. Results indicate that differences in the policies for screening prostate-specific antigen (PSA) at the national level may contribute to the noticeable variations in prostate cancer rates globally.

On the other hand, the widespread use of PSA as a blood marker has significantly improved the diagnosis of prostate cancer cases. However, it is worth noting that PSA is an indicator of prostate diseases in general, not specifically prostate cancer, as PSA levels may rise in conditions such as benign prostatic hyperplasia or prostatitis. Consequently, research continues in developing more precise standards for diagnosing prostate cancer, which include thorough examination of PSA derivatives such as the free-to-total PSA ratio and PSA density.

PSA density represents a strong indicator; as PSA density increases, the likelihood of diagnosing prostate cancer rises. Thus, PSA density has proven to achieve higher diagnostic accuracy compared to reliance on PSA alone.

Data Analysis and Methods Used in the Study

The study conducted at Beijing Qinghua Changgung Hospital between November 2014 and March 2024 involved 410 patients who underwent prostate biopsy using transrectal ultrasound techniques. Patients were classified into two groups: one representing prostate cancer and the other representing benign prostatic hyperplasia based on histopathological results.

The researchers in this study gathered to analyze the clinical and histological materials, focusing on defining various terms for PSA density such as PSADadj, which takes body weight into account, and this method aims to bridge the gap resulting from changes in blood levels due to differences in body sizes. The researchers’ experience with Chinese patients considers population differences, in addition to the fact that PSADadj-based screening and diagnosis is used to assist in making biopsy decisions.

The collected data were analyzed based on strict criteria, identifying a set of clinical characteristics such as age, body mass index (BMI), PSA examination results, and magnetic resonance imaging findings. The statistical aspect included deriving outcomes through various statistical methods to analyze the relationship between different parameters and their impact on biopsy results.

Study Results and Clinical Applications of PSADadj

The study demonstrated that PSADadj had a high diagnostic capability for the early detection of prostate cancer. The study recorded diagnostic rates of 19.075 for the incidence of prostate cancer based on PSAD, making PSADadj a strong indicator compared to other PSA-related benchmarks.

With

When PSA levels increase, PSADadj is not only less accurate but also shows higher accuracy in detecting prostate cancer in patients with PSA levels in the gray area compared to other PSA standards. The area under the receiver operating characteristic curve (AUC) for PSADadj was 0.780, indicating notable diagnostic accuracy. Sensitivity of 63.3% and specificity of 81.6% were also noted as evidence of the effectiveness of PSADadj.

Furthermore, it was confirmed that PSADadj can reduce the number of unnecessary biopsies, which is extremely important given the costs and potential side effects involved. PSADadj can be used as a reliable indicator when there are undefined PSA levels, providing urologists with additional support in making biopsy decisions.

Future Prospects in Prostate Cancer Diagnosis

Many questions remain regarding how to use PSADadj more effectively and fairly across all populations. In the current context where disease rates vary significantly from region to region, the need for additional studies to use PSADadj in different communities remains. As this method becomes more popular, the opportunities to improve diagnostic accuracy and reduce patient disturbances due to late diagnosis increase.

Additionally, there is an urgent need to develop standardized global criteria that can be applied across countries concerning PSA density. Thus, investing in and researching PSA and PSADadj can help alleviate the burden on the healthcare system and achieve better resources in diagnosis and treatment.

Ultimately, the benefit of applying PSADadj in diagnosing prostate cancer lies in contributing to global efforts to provide better healthcare for men at risk for this type of cancer. Such studies contribute to the continuous support of scientific research and innovation in modern medicine and prevention.

Methods of Prostate Cancer Detection and PSA Effects

Prostate cancer is one of the most prevalent types of cancer among men. Doctors and specialists rely on a set of biomarkers to discover this cancer, the most prominent of which is prostate-specific antigen (PSA). This antigen is secreted by prostate cells and can be measured in the blood. PSA levels play a crucial role in diagnosing prostate cancer, as elevated levels may indicate the presence of cancer. However, PSA is not entirely specific, as elevated levels can also point to other conditions such as benign prostatic hyperplasia (BPH) and prostatitis. Therefore, additional indicators like the ratio of free PSA to total PSA (f/t PSA) and PSA density (PSAD) are utilized to enhance diagnostic accuracy.

In many studies, the potential impacts of each of these indicators on the early detection of prostate cancer have been analyzed. Some research has shown that increased age and total PSA levels can raise the likelihood of cancer, while increases in prostate volume are considered negative factors related to detecting the disease. This requires doctors to exercise caution when interpreting PSA results, especially among men who might have PSA values in the gray area between 4-10 ng/mL.

The Relationship Between Patient Age and Medical Test Results

A recent study showed a positive relationship between the patient’s age and health issues related to the prostate, including prostate cancer. As a man’s age increases, so do the chances of developing prostate cancer. However, it was found that prostate volume had a negative effect on detecting the disease. For instance, as the prostate volume increased, the proportion of cancerous tissues present in the sample taken during the biopsy decreased. This suggests that even with elevated PSA levels, it does not necessarily indicate cancer presence, especially in cases of prostate enlargement.

Therefore,
scientists and doctors are working on developing predictive models that take into account age, prostate size, and other biochemical indicators to achieve the best possible accuracy in diagnosis. One of these models relies on a diverse analysis of a set of clinical factors, including PSA ratios and other metrics, which enhances doctors’ ability to predict the disease at an early stage.

Innovations in PSA Use and New Predictive Models

As medicine continues to evolve, new metrics have been introduced to improve the accuracy of prostate cancer diagnosis. Among these metrics, the use of modified PSAD has been proposed. The modified PSAD represents a new number calculated by adjusting the PSA density based on the patient’s weight. Research indicates that this modification provides higher diagnostic value compared to traditional values. Additional indicators such as modified PSAD offer more precise information about a man’s health status, equipping doctors with better tools to engage with the disease and deliver early and effective treatment plans.

In many cases, these improved estimates can lead to better decisions regarding biopsies, confirmation of diagnoses, and whether to initiate treatment early. Additionally, some studies have highlighted the effectiveness of modified PSAD in identifying prostate cancer among men with PSA levels in the gray area. This suggests that this new measurement could change the way the risk of this disease is assessed in clinical teams.

Challenges in Diagnosing Prostate Cancer and the Role of Multiple Tests

Doctors face multiple challenges when diagnosing prostate cancer, necessitating the use of several tests and indicators. Given the significant overlap between PSA results and benign prostate levels, it means that doctors need to rely on multiple diagnostic methods to enhance confidence in the results. This includes using imaging techniques such as multiparametric MRI (mpMRI) to accurately determine prostate size, allowing doctors to reduce diagnostic errors.

Moreover, studies indicate the importance of using multiple biological tests to standardize results. Relying solely on PSA results can miss opportunities for diagnosing prostate cancer in early and treatable stages. Therefore, it is essential for doctors to stay informed about the latest research and technologies used in this field to ensure they provide the best healthcare to patients.

Future Conclusions Regarding Prostate Cancer

Research is ongoing to improve prostate cancer screening through new indicators and innovative diagnostic strategies. Future studies may highlight the importance of using modified PSAD and investigate how to integrate it with existing tests to achieve the best outcomes. It will also be crucial to ensure the comprehensive implementation of these methods in clinical practices, enabling healthcare professionals to provide reliable and effective care. The medical community needs greater awareness of the risks of prostate cancer and the available techniques to mitigate these risks, contributing to improved quality of life for patients and the suitability of treatments offered to them.

Determining Optimal Thresholds for Prostate-Specific Antigen Density (PSAD)

Prostate-specific antigens (PSA) are key tools in diagnosing prostate cancer, and the PSA density index (PSAD) is used as an effective tool in evaluating the risk of developing this type of cancer. Studies have shown that the optimal thresholds for the PSAD index vary according to the distribution of clinical samples. In these studies, a PSAD threshold of 0.282 was identified to yield a sensitivity of 59.9% and a specificity of 84.0%. Meanwhile, the threshold for the modified PSAD index (PSADadj) was 17.804, with a sensitivity of 63.3% and a specificity of 81.6%. We should be aware that these thresholds were determined upon achieving the highest value of Youden’s index, indicating the importance of those measurements in making biopsy decisions during population screening.

In comparison,

Previous studies, such as the study by Tiu and colleagues, have reached similar results, showing that a PSAD threshold of 0.1 has relatively high sensitivity but lower specificity. This indicates that thresholds can reflect different trends based on populations and medical contexts. We must consider that tests in areas where PSA levels fall within an ambiguous range (between 4 and 10 ng/mL) may lead to misdiagnosis. A significant proportion of men in this range do not have prostate cancer. Therefore, it is essential to use new measurements such as the PSADadj index to enhance diagnostic accuracy.

The PSADadj results are more accurate in predicting prostate cancer compared to other criteria such as PSAD and traditional measures, making it a reliable candidate for use in future diagnoses. The results clearly show that these indicators provide strong support to physicians and specialists when guiding targeted biopsies, which can ultimately reduce unnecessary procedures and increase positive indicators.

Clinical Importance of the Prostate-Specific Antigen Density Index

The importance of discussing PSAD in the medical field is increasing as it improves the ability to differentiate between prostate cancer and benign prostatic hyperplasia (BPH). Understanding PSAD levels is important as it enhances the ability to make more informed treatment decisions regarding whether physicians should perform biopsies for accurate diagnosis. Studies have shown that elevated PSAD levels can be an excellent indicator of the likelihood of cancer, while low levels indicate a lack of this risk.

When dealing with patients who have PSA values in the “ambiguous” range, using PSAD helps reduce the rate of false biopsy requests, improving the clinical experience for patients and reducing the anxiety that may arise from these medical procedures. For example, if we can rely on PSAD as a primary guide, physicians can direct patients toward careful monitoring instead of unnecessary biopsies, saving a considerable amount of time and effort. Thus, PSAD enhances the complex diagnostic process and enables physicians to avoid potentially costly errors.

Additionally, the use of PSADadj has resulted in positive outcomes in evaluating diagnostic effectiveness. Classifying the new index according to different life contexts (such as weight, general health, and genetic factors) can enhance predictive accuracy. However, several elements must be considered, such as the need for additional clinical data from various centers to ensure the reliability of the specified values. This can lead to the preparation of the necessary data to formulate accurate models based on the appropriate thresholds for each case. Therefore, it is important to continue monitoring the use of PSADadj and ensure its effectiveness through a wide range of future clinical research.

Future Challenges in Using PSADadj

Despite the significant improvement in using PSADadj, challenges and areas needing further research in the clinical use of this index remain. We must consider weight-related factors that have been shown to affect blood vitality distribution in patients, especially those with chronic health conditions like heart failure or hypoalbuminemia. Therefore, PSADadj cannot be considered a reliable indicator for all patients, which opens the door for more research to develop new thresholds suitable for each treatment category.

Moreover, there may be discrepancies in estimating prostate volume across different tests. For instance, MRI may be more accurate in measuring prostate volume compared to conventional X-rays or other examinations. This discrepancy can have a significant impact on the values of PSAD and PSADadj. Thus, applying advanced techniques such as artificial intelligence in estimating prostate volumes may have a substantial impact on the accuracy of outcomes arising from PSADadj.

In conclusion

the methodology of collecting patient data systematically while ensuring ethical considerations were met. The results indicated a significant correlation between elevated PSADadj levels and the likelihood of prostate cancer diagnosis. In our analysis, patients with higher PSADadj had a greater incidence of positive biopsy results, highlighting the potential of this adjusted measurement as a reliable biomarker for prostate cancer in this specific population.

Furthermore, our findings suggest that incorporating PSADadj into routine screening protocols may lead to improved diagnostic accuracy and reduced unnecessary biopsies. This can ultimately result in better patient outcomes, as earlier detection of prostate cancer can facilitate timely and appropriate treatment options.

دور البحث والتطوير المستقبلي

يتطلب تعزيز استخدام PSADadj مزيدًا من الأبحاث المستمرة لجمع البيانات على نطاق أوسع، بما في ذلك دراسات متعددة المراكز وتعاون دولي. كما يجب النظر في تطوير نماذج إحصائية أكثر دقة تأخذ في الاعتبار العوامل المختلفة التي تؤثر على مستويات PSA وPSADadj، بما في ذلك العوامل الوراثية والعوامل البيئية والسلوكيات الصحية.

علاوة على ذلك، يمكن أن تساهم التكنولوجيا الحديثة، مثل الذكاء الاصطناعي وتعلم الآلة، في تحليل البيانات بشكل أعمق وتوفير رؤى جديدة حول كيفية استخدام PSADadj في تحسين التشخيص والعلاج السريري. وهذا يتطلب أيضاً العمل على تأسيس معايير وتوجيهات واضحة لاستخدام PSADadj في الممارسات السريرية، لضمان توافر أدوات دقيقة وآمنة للأطباء في مختلف أنحاء العالم.

في الختام، يعد PSADadj أداة واعدة يمكن أن تلعب دوراً هاماً في تحسين تشخيص سرطان البروستاتا وتعزيز الرعاية الصحية للمرضى. يتطلب تحقيق هذا الإمكانات إجراء المزيد من الأبحاث واستثمارات في تطوير الأنظمة الوقائية والعلاجية. من خلال التركيز على تصحيح قياسات PSA وتحسين العلاجات المستهدفة، يمكننا تعزيز تجارب المرضى وتحسين نتائجهم الصحية على المدى الطويل.

The criteria set by the Chinese Urological Association for determining biopsy indications, including suspicious masses and positive PSA test results. Patients who had previously undergone prostate puncture procedures or those with complex medical conditions that could affect examination results were excluded.

Our results showed that the use of PSADadj has gone a long way in improving the diagnostic accuracy of prostate cancer, as the performance characteristics of both PSAD and PSADadj were positively related to prostate biopsy outcomes. Additionally, there was increased attention to factors affecting PSAD results, such as patient weight and prostate size, emphasizing the importance of incorporating such variables into clinical records. The outcome is the potential reduction of unnecessary biopsy cases and an increase in accurate diagnostic measures.

Future Recommendations for Research and Clinical Applications

The findings derived from the current research make it essential to continue studying the impact of weight and prostate size on PSA assessment results. Furthermore, providing more accurate diagnostic tools can help address the increasing challenges associated with rising prostate cancer rates, especially in regions with diverse population characteristics. The recommendation includes the imperative necessity to develop joint screening protocols that take cultural and environmental differences into account.

Researchers should also continue to study PSADadj as a dimension under investigation not only in China but globally, including comparing it with current standards used in diagnosing prostate cancer. These studies can contribute to creating more comprehensive and evidence-based screening processes, ultimately leading to improved clinical outcomes for patients.

The results we obtained also support the importance of knowledge transfer among clinical practitioners and its application in real-life, as providing additional awareness on how to use these diagnostic tools in everyday medical practices could improve patient care. Embracing active surveillance and careful screening based on new data will mark the beginning of a new era in the diagnosis and treatment of prostate cancer.

Prostate Imaging Screening Using MRI Techniques

The comprehensive examination of the prostate involves the adoption of modern MRI techniques, which are considered a cornerstone in assessing cases related to the risk of prostate cancer. The process typically starts with a 3 Tesla MRI scan, which is relied upon to accurately gather information about prostate tissues. Multiple imaging protocols are used, including T1-weighted imaging, T2-weighted imaging, diffusion imaging, and dynamic contrast-enhanced imaging. Each technique provides unique information that enhances the understanding of the prostate condition. Studies are evaluated using a prostate imaging reporting data system, which aims to classify the results based on specific scores indicating the likelihood of cancer presence, contributing to an accurate decision regarding biopsy procedures.

The use of MRI in guiding biopsy procedures is a vital step, as the MRI results are combined with ultrasound guidance to help direct the biopsy tool to potential sites where cancerous cells may be present. Tissue samples are taken from various areas of the prostate, ensuring that samples encompass multiple regions to avoid missing any potential tumors. This process aids in determining the form and type of cells present, influencing the subsequent treatment strategy based on the examination results.

Statistical Data Analysis and Predictive Factors

Statistical data analysis is a critical step for understanding the relationship between various risk factors and prostate cancer occurrences. Through comprehensive patient data surveys, they are divided into two main groups; the prostate cancer group and the benign prostatic hyperplasia group. The analysis of means and standard deviations, alongside unpaired t-tests and χ² tests, is used to estimate changes between the two groups. The results clearly indicate that standards, such as age, total PSA, and PSAD ratio, were significantly higher in the prostate cancer group compared to the other group. Major differences in results also show that the level of PSA has a significant impact on the accuracy of diagnosis.

It requires
statistical analyses using multivariate logistic regression techniques to assess the relationship between various factors and diseases. It is evident that the relationship between patient age, PSA levels, and positive MRI outcomes was positive in the presence of prostate cancer, while there is a negative correlation with prostate size. The goal here is to provide reliable indicators that offer accurate information about the likelihood of prostate cancer, which may lead to early interventions that could save patients’ lives.

Performance of New Criteria in Predicting Prostate Cancer

One of the innovations in the diagnosis of prostate cancer is the new marker known as PSADadj, which has been established through extensive studies. This marker surpasses traditional benchmarks known such as the total PSA estimate or PSAD ratio, as it offers greater accuracy in detecting prostate cancer, particularly in the high-risk age group. The PSADadj ratio relies on incorporating patient weight, which makes it a more accurate risk indicator.

When analyzing the diagnostic performance of this marker, Receiver Operating Characteristic (ROC) curves were used to determine cut-off values that can be utilized to identify patients who may have potential cancers. It was found that PSADadj has the highest area under the curve value compared to other standards, indicating that it provides a comprehensive mix of sensitivity and good specificity.

The results are intriguing as they have proven that the sensitivity level for performing biopsies may exceed that of other indicators, providing physicians with more reliable information when making decisions for therapeutic intervention. These results demonstrate that new markers such as PSADadj may change the way prostate function is assessed, enabling earlier and more accurate diagnoses of prostate cancer.

Practical Impact of the Results and Importance of Future Research

The results presented from the research are of utmost importance in guiding clinical strategies for diagnosing prostate cancer. Not only do they provide a new tool for improving diagnostic accuracy, but they also encourage a deeper understanding of the factors responsible for the disease. Furthermore, these analyses lead to improved levels of healthcare provided to patients, as each step of treatment requires a complex interaction between medical information management and test results.

The role of future research is enhanced through a focus on new markers and aligning modern imaging techniques with the examinations performed. We must promote collaboration between various medical and research specialties to identify more influencing factors in early diagnosis and accurate follow-up of cases. Further research into opportunities for improving imaging and individual risk factors should be a part of this effort, contributing to the development of more effective treatments and providing better healthcare for patients in the future.

Basics of the PSA Marker and Its Role in Diagnosing Prostate Cancer

The PSA (Prostate-Specific Antigen) marker is an important tool in diagnosing prostate cancer; it is an enzyme produced by prostate cells and can be released into the bloodstream when prostate tissue is damaged due to tumors or benign lesions. However, elevated PSA levels are not a definitive indicator of prostate cancer, as high PSA levels can overlap with other conditions such as benign prostatic hyperplasia (BPH) and prostatitis. Therefore, in the presence of overlapping values, there is an urgent need for additional indicators to improve the accuracy of clinical diagnosis.

The PSAD marker (PSA Density) is widely used in clinical practice, relying on the ratio of PSA level to prostate size. However, there is no established standard for estimating prostate size, making the results vary among the techniques used. Multi-parametric MRI (mpMRI) and transrectal ultrasound (TRUS) are among the most commonly used techniques. Previous studies have indicated that mpMRI offers more accurate estimates of prostate size compared to TRUS, highlighting the importance of choosing the appropriate technique for estimating prostate size as part of the diagnostic process.

One of
to that, it is essential to establish standardized protocols for measuring prostate volume to ensure comparability across studies. This would aid in refining diagnostic criteria and improving patient outcomes. Future research endeavors should also focus on long-term follow-up of patients to assess the clinical impact of incorporating PSADadj in routine practice.

Conclusion

The study highlights the potential of the PSADadj metric in enhancing the accuracy of prostate cancer diagnosis. As the medical community continues to seek effective biomarkers, integrating new approaches like PSADadj may lead to more informed decision-making and improved management strategies for patients at risk of prostate cancer. Ongoing investigation into related factors and technological advancements will be crucial in shaping the future of prostate cancer diagnostics.

To that end, the methods used to study the links between multiple factors in prostate cancer incidence require continuous scrutiny to ensure definitive and reliable results. Additionally, collaboration among different medical centers may contribute to the exchange of knowledge and facilitate joint studies that enhance scientific research in this vital field.

In conclusion, with the advancement of research and new discoveries, PSADadj has the potential to become a key standard in the diagnosis of prostate cancer, emphasizing the ongoing importance of clinical research in health care. The use of more accurate and robust indicators is likely to enhance the quality and service of health care provided to patients, thereby facilitating the early and effective detection of prostate cancer.

Formal Analysis and Data

Formal analysis is a fundamental process that involves the careful evaluation of information and data to identify relevant patterns and trends. Formal analysis is associated with data collection, organization, and processing in a manner that contributes to providing valuable insights. These processes include several stages, starting from sample selection to result analysis. For example, in the field of medical research, researchers analyze clinical outcomes to determine the effectiveness of various treatments. In the context of scientific research, data are analyzed using statistical tools and interpreting results to draw conclusions that support the studied hypotheses.

One of the methods used in formal analysis is the analysis of qualitative and quantitative data. While qualitative focuses on understanding phenomena and behaviors through surveys and interviews, quantitative focuses on statistical numbers. This combination of both can generate useful results that support research innovations. For example, data analysis can be employed to understand the factors affecting the spread of certain diseases by collecting data from multiple hospitals and analyzing it interactively.

Moreover, the methodology of analysis is a pivotal factor to facilitate data examination. This methodology involves appropriate steps for data qualification, such as cleaning the data, filtering out unnecessary data, and then applying appropriate statistical analysis techniques. The adopted methodology depends on the type of data and the purpose to be achieved. It is very important that every step of the data analysis is recorded to ensure transparency and reproducibility, assisting scientists and researchers in obtaining reliable results.

Securing Funding and Resources

Securing funding is a vital step in any research project, as it determines the technologies, tools, and resources available to researchers. Researchers often seek research grants from academic, governmental, or even private sector institutions. Funding can come in various forms such as educational grants, technical grants, or direct aid. In the case of medical research, for example, researchers may receive funding from health organizations aimed at promoting research in specific diseases.

Submitting a funding application requires a precise methodology. Researchers must clarify the main objectives of the project, the steps they will implement, and how they will effectively utilize the funds. Many funding applications also require providing previous data on related research to ensure that projects are not duplicated. When researchers secure funding, this allows them to benefit from the necessary resources to conduct experiments and publish results.

For instance, one study received financial support to develop a new treatment for cancer, as the research team utilized the allocated resources to conduct laboratory studies and clinical trials. Without such funding, it might be challenging to acquire the necessary equipment and hire personnel. After the research is completed, funding institutions usually monitor the results to ensure that the funds are used in a manner that achieves public benefit.

Supervision and Validation

Supervision plays a vital role in ensuring the reliability and usefulness of results in scientific research. Supervision helps control the quality of research by overseeing all stages of the project and guiding researchers on how to process and analyze data. Medical research, for example, requires careful supervision to ensure that all ethical protocols are followed and that all experiments are conducted according to specified standards. Weak supervision can lead to inaccurate results or even adversely affect the safety of participants in trials.

Platforms

Good supervision involves the continuous evaluation of performance, where work is reviewed for errors and compliance with health and ethical regulations is ensured. Multiple verification techniques are also used to review outcomes, such as periodic information reviews and checking for bias in the data. This is crucial as it ensures that the results obtained truly represent the actual effectiveness of the treatment or solution being tested.

Additionally, the validation process enhances the credibility of the research. It requires sharing the results with the scientific community through peer-reviewed publications or scientific conferences. Results without investigation or confusing supervision can expose research to significant risks, as it will be difficult to replicate experiments or verify results by other researchers. Therefore, oversight and verification play a central role in enhancing trust in science and medical research.

Source link: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1462997/full

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