Genetic analysis identifies risk loci for cannabis use disorder and shows overlap with impulsivity and psychopathology.
Overview
Genetic data and genetic analysis of patients provide an overview of the heredity of cannabis use disorder and reveal the overlap with impulsivity and psychopathology. Potential risk loci are identified, and genes associated with this disorder are analyzed.
Heritability and Epidemiology of the Barcoded Hematopoietic Clonal Disorder
The barcode-based method in the UK Biobank and the Icelandic cohort is used to identify causative factors for hematopoietic clonal disorder and finds associations between the disorder and multiple diseases. Genome-wide gene aggregating analysis identifies 25 loci associated with barcode exposure.
Transcriptional Regulators and Epigenomics of Human CD8+ T Cell Function Defined by Orthogonal CRISPR Screens
CRISPR activation/interference screens identify transcriptional regulators of human CD8+ T cells, including BATF3. Increased T cell exhaustion and enhanced cancer immunotherapy occur in vivo models.
Super-enhancer m6A RNA Enhances Local Chromatin Accessibility and Tumor Transcription in Pancreatic Ductal Adenocarcinoma
In pancreatic ductal adenocarcinoma, super-enhanced RNAs (seRNAs) exhibit higher levels of N6-methyladenosine (m6A) than adjacent normal tissues due to activation of the METTL3 co-factor CFL1. Super-enhanced RNAs promote tumor transcription through the YTHDC2-MLL1 complex.
The barcode-based method in the UK Biobank and the Icelandic cohort is used to identify causative factors for hematopoietic clonal disorder (CH) and finds associations between the disorder and multiple diseases. Genome-wide gene aggregating analysis identifies 25 loci associated with barcode exposure.
Authors:
Simon N. Stacey Florian Zink Kari Stefansson
Publication Date:
November 6, 2023
CRISPR activation/interference screens identify transcriptional regulators of human CD8+ T cells, including BATF3. Increased T cell exhaustion and enhanced cancer immunotherapy occur in vivo models.
Authors:
Sean R. McCutcheon Adam M. Swartz Charles A. Gersbach
Publication Date:
November 9, 2023
In pancreatic ductal adenocarcinoma, super-enhanced RNAs (seRNAs) exhibit higher levels of N6-methyladenosine (m6A) than adjacent normal tissues due to activation of the METTL3 co-factor CFL1. Super-enhanced RNAs promote tumor transcription through the YTHDC2-MLL1 complex.
Authors:
Rui Li Hongzhe Zhao Jian Zheng
Publication Date:
November 13, 2023
Age-related transcriptional stress occurs due to accelerated elongation and increased pausing in RNAPII. A whole-genome analysis is conducted to identify genetic influences on blood flow in the heart and aortic valve.
Authors:
Antonios Papadakis Akos Gyenis Andreas Beyer
Publication Date:
November 24, 2023
This article presents a Pantu perspective on genetic medicine in Africa and highlights the importance of developing genetic research on the African continent. It underscores the opportunities and challenges facing genetic research in Africa and promotes the need for infrastructure development and international collaboration in this field.
Author:
Aimé Lumaka
Publication Date:
November 13, 2023
In memory of Jeanette Erdmann, this obituary is published to honor her outstanding contributions to genomics and genetic research. The obituary highlights her scientific legacy and impact on the scientific community.
Authors:
Redouane Aherrahrou Thomas Eschenhagen Zouhair Aherrahrou
Publication Date:
November 20, 2023
This article discusses complex synthetic lethality in cancer and how it can be utilized in cancer treatment. Various mechanisms of synthetic lethality and their potential applications in cancer therapy are analyzed.
Authors:
Colm J. Ryan Lovely Paul Solomon Devakumar Christopher J. Lord
Publication Date:
November 30, 2023
This article reevaluates the use of structural similarity index in Hi-C and presents new perspectives on its benefits and limitations. Current studies are reviewed, and recommendations are made to improve the use of structural similarity index in Hi-C.
Authors:
Hanjun
Lee Bruce Blumberg Toshihiro Shioda
Publication date:
December 5, 2023
This response addresses the previous article regarding the use of the structural similarity index in Hi-C and clarifies some additional points and explanations. A detailed response is provided to the points raised in the previous article.
Authors:
Elizabeth Ing-Simmons Nick Machnik Juan M. Vaquerizas
Publication date:
December 5, 2023
Source: https://www.nature.com/ng/
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